Methylenedioxy methamphetamine
MDMA
What it isSerotonin, norepinephrine and dopamine releaser; investigational for PTSD.
Why this oneIts prosocial and fear-attenuating effect is the rationale for psychotherapy-assisted use.
What limits it⚑ Hyperthermia and hyponatremia cause the deaths, not the drug’s direct toxicity. Serotonin syndrome with MAOIs; FDA declined approval in 2024.
FDA-approved for
- PTSD (investigational; not approved)
Off-label
- PTSD (phase 3; FDA declined approval in 2024)
NO BOXED WARNINGS
Principal risk⚑ Hyperthermia and hyponatremia cause the deaths, not the drug’s direct toxicity
Classes and tags
Clinical profile
Mechanism of action: Methylenedioxy methamphetamine ballicule
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