GI-restricted (minimal systemic absorption)

Interaction at a glance

• Acts mainly within the GI lumen/wall

Mechanism

• Acts mainly within the GI lumen/wall
• Systemic bioavailability is minimal
• Local GI effects still matter

Magnitude / time course

• Severe mucosal disease can occasionally alter exposure

Management

• Systemic adverse effects/DDIs are often reduced

Self-check

• What major clinical effect is associated with GI-restricted (minimal systemic absorption)?
  Systemic adverse effects/DDIs are often reduced.

Drugs in this interaction (20)

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