CYP2C19 substrate
- Cleared substantially by CYP2C19
- CYP2C19 inhibitors can raise exposure
- CYP2C19 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype strongly affects several substrates.
Interaction at a glance
- Cleared substantially by CYP2C19
Mechanism
- Cleared substantially by CYP2C19
Magnitude / time course
- CYP2C19 inhibitors can raise exposure
- CYP2C19 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype strongly affects several substrates.
Self-check
- What can happen to CYP2C19-substrate exposure when CYP2C19 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP2C19-substrate interaction?
Fraction metabolized.
Drugs in this interaction (23)
All interaction examples · Open CYP2C19 substrate in the interactive console ↗