CYP2C19 substrate
- Cleared substantially by CYP2C19
- CYP2C19 inhibitors can raise exposure
- CYP2C19 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype strongly affects several substrates.
Interaction at a glance
- Cleared substantially by CYP2C19
Mechanism
- Cleared substantially by CYP2C19
Magnitude / time course
- CYP2C19 inhibitors can raise exposure
- CYP2C19 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype strongly affects several substrates.
Self-check
- Which pathway substantially clears drugs tagged as CYP2C19 substrate?
CYP2C19.
Drugs in this interaction (23)
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