Poorly dialyzable

Interaction at a glance

• Hemodialysis removes little clinically useful drug

Mechanism

• Hemodialysis removes little clinically useful drug
• Large Vd/high protein binding are common reasons

Mechanism / modifiers

• Tissue sequestration can make plasma removal futile

Mechanism / exceptions

• Supportive care/antidote may matter more
• “Poorly” can vary with dialysis technology

Self-check

• What does “Poorly dialyzable” mean?
  Hemodialysis removes little clinically useful drug.

Drugs in this interaction (19)

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