Ionization (permanently charged)

Interaction at a glance

• Carries a fixed ionic charge

Mechanism

• Carries a fixed ionic charge
• Passive lipid-membrane diffusion is limited

Mechanism / modifiers

• BBB penetration is usually poor

Mechanism / exceptions

• Distribution often favors extracellular space
• Transporters may still enable tissue entry

Self-check

• What does “Ionization (permanently charged)” mean?
  Carries a fixed ionic charge.

Drugs in this interaction (16)

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