Ionization (permanently charged)

Interaction at a glance

• Carries a fixed ionic charge

Mechanism

• Carries a fixed ionic charge
• Passive lipid-membrane diffusion is limited

Mechanism / modifiers

• BBB penetration is usually poor

Mechanism / exceptions

• Distribution often favors extracellular space
• Transporters may still enable tissue entry

Self-check

• How does permanent charge affect passive lipid-membrane diffusion?
  It limits diffusion.
• Can transporters enable tissue entry of permanently charged drugs?
  Yes.

Drugs in this interaction (16)

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