CYP3A4 inhibitor

Interaction at a glance

• Inhibits CYP3A4

Magnitude / time course

• Inhibits CYP3A4
• CYP3A4 substrate exposure can rise

Mechanism

• Effect is greatest for sensitive substrates
• Inhibition often begins faster than induction
• Largest DDI burden; gut + liver both contribute.

Clinical consequence

• Toxicity risk rises with narrow-index victims

Self-check

• What is the main clinical risk of CYP3A4 inhibitor?
  Toxicity risk rises with narrow-index victims.
• Which enzyme or transporter is central to the CYP3A4 inhibitor interaction?
  CYP3A4.

Drugs in this interaction (19)

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