CYP3A4 inhibitor

Interaction at a glance

• Inhibits CYP3A4

Magnitude / time course

• Inhibits CYP3A4
• CYP3A4 substrate exposure can rise

Mechanism

• Effect is greatest for sensitive substrates
• Inhibition often begins faster than induction
• Largest DDI burden; gut + liver both contribute.

Clinical consequence

• Toxicity risk rises with narrow-index victims

Self-check

• Key risk with CYP3A4 inhibitor?
  Toxicity risk rises with narrow-index victims.
• How does the onset of CYP3A4 inhibition often compare with induction?
  Inhibition often begins faster.

Drugs in this interaction (19)

All interaction examples · Open CYP3A4 inhibitor in the interactive console ↗