Grapefruit juice
furanocoumarin
What it isFuranocoumarin-containing juice that irreversibly inhibits intestinal CYP3A4.
Why this oneIt is not a drug but behaves like a strong inhibitor, and one glass can raise a substrate severalfold.
What limits itBecause the enzyme must be resynthesised, the effect lasts about three days — separating doses does not help.
NO BOXED WARNINGS
Principal riskIrreversible CYP3A4 inhibition lasting about three days
Classes and tags
Clinical profile
Mechanism of action: Grapefruit juice ballicule
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