CYP2D6 phenotype-sensitive
- Clinical exposure depends strongly on CYP2D6 phenotype
- Genotype can shift efficacy and toxicity
- Strong inhibitors can mimic poor metabolism
- Prodrugs may show the opposite efficacy pattern
- Poor-to-ultrarapid phenotypes can alter response.
Interaction at a glance
- Clinical exposure depends strongly on CYP2D6 phenotype
Mechanism
- Strong inhibitors can mimic poor metabolism
Magnitude / time course
- Clinical exposure depends strongly on CYP2D6 phenotype
Clinical consequence
- Genotype can shift efficacy and toxicity
- Prodrugs may show the opposite efficacy pattern
Mechanism / modifiers
- Poor-to-ultrarapid phenotypes can alter response.
Self-check
- What is the main clinical risk of CYP2D6 phenotype-sensitive?
Genotype can shift efficacy and toxicity.
Drugs in this interaction (23)
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