H1 antihistamines

Class at a glance

• Block/inversely agonize H1 receptors

Clinical role

• Treat allergy, itch + urticaria

Other clinical roles

• Some 1st-gen drugs are antimuscarinic
• Not adequate treatment for anaphylactic shock

Safety / monitoring

• 1st-gen drugs cross BBB and sedate
• 2nd-gen drugs are usually less sedating

Self-check

• What is the main pharmacologic action of H1 antihistamines?
  Block/inversely agonize H1 receptors.

Drugs in this class (16)

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