Antimuscarinics
- Block muscarinic acetylcholine signaling
- Uses depend on organ + route
- OAB, COPD, EPS, motion sickness, GI spasm
- Dry mouth, constipation, urinary retention
- Confusion/memory impairment esp older adults
- Can precipitate angle-closure glaucoma
- Peripheral drugs cause less CNS toxicity
Class at a glance
- Block muscarinic acetylcholine signaling
Practical pearls
- Confusion/memory impairment esp older adults
Clinical role
- Uses depend on organ + route
- OAB, COPD, EPS, motion sickness, GI spasm
- Can precipitate angle-closure glaucoma
Safety / monitoring
- Dry mouth, constipation, urinary retention
- Peripheral drugs cause less CNS toxicity
Self-check
- What type of glaucoma can antimuscarinics precipitate?
Angle-closure glaucoma. - How does peripheral restriction affect antimuscarinic CNS toxicity?
Peripheral drugs cause less.
Drugs in this class (20)
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