ACE inhibitors

Class at a glance

• RAAS blockers → ↓ Ang II/aldosterone

Clinical role

• HTN, HFrEF, albuminuric CKD
• Strong outcomes data; inexpensive

Practical pearls

• Cough/angioedema from bradykinin
• Do not routinely combine with an ARB

Safety / monitoring

• Hyperkalemia + creatinine rise possible
• Avoid in pregnancy/bilateral renal stenosis

Self-check

• When should ACE inhibitors generally be avoided?
  pregnancy/bilateral renal stenosis.
• Should ACE inhibitors routinely be combined with an ARB?
  No.

Drugs in this class (17)

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