Major depressive disorder (MDD)
- Psychotherapy and/or antidepressant first
- SSRI/SNRI/bupropion/mirtazapine common
- Choose by symptoms, AEs + comorbidity
- Optimize after an adequate dose/duration
- Partial response → optimize or augment
- atypical antipsychotic/lithium options
- Nonresponse → switch drug or mechanism
- Severe/psychotic/catatonic → consider ECT
Use at a glance
- Psychotherapy and/or antidepressant first
Practical pearls
- SSRI/SNRI/bupropion/mirtazapine common
- Optimize after an adequate dose/duration
Treatment options
- Partial response → optimize or augment
- atypical antipsychotic/lithium options
- Nonresponse → switch drug or mechanism
Other practical pearls
- Choose by symptoms, AEs + comorbidity
- Severe/psychotic/catatonic → consider ECT
Self-check
- What should be optimized in Major depressive disorder (MDD)?
after an adequate dose/duration.
- What is the first management step in Major depressive disorder (MDD)?
Psychotherapy and/or antidepressant.
Drugs used for this (35)
All clinical uses · Open the interactive console ↗
