Antioxidant
- Scavenges reactive oxygen species/free radicals
- Protects lipids, proteins and DNA from oxidative damage
- Clinical benefit in trials has rarely matched the biochemical rationale
- Replenishes glutathione in acetaminophen overdose
Drugs with this mechanism (7)
- Curcumin — Turmeric constituent; poorly absorbed anti-inflammatory with real CYP interactions.
- Glutathione — Cell’s main thiol antioxidant and conjugation substrate; depleted by acetaminophen overdose, repleted by NAC.
- Kaempferol — Dietary flavonoid antioxidant.
- Quercetin — Dietary flavonoid antioxidant supplement.
- Rutin — Dietary flavonoid antioxidant.
- Saffron — Botanical studied for depressive symptoms; small trials suggest benefit, but long-term evidence and product standardization are limited.
- Vatiquinone — Investigational redox-active 15-lipoxygenase inhibitor for Friedreich ataxia; clinical benefit remains unestablished.
Self-check
- How has antioxidant clinical benefit generally compared with biochemical rationale in trials?
It has rarely matched the rationale. - What antioxidant reserve is replenished in acetaminophen overdose?
Glutathione.
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