Curcumin
turmeric
What it isThe principal curcuminoid of turmeric, inhibiting NF-kB and several inflammatory pathways.
Why this oneIt is the most studied dietary anti-inflammatory, with modest trial evidence in osteoarthritis.
What limits it⚑ Oral bioavailability is very low, which is why products add piperine — and piperine itself inhibits CYP3A4 and P-gp. Curcumin inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect.
NO BOXED WARNINGS
Principal riskIt inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect
Classes and tags
Clinical profile
Mechanism of action: Curcumin ballicule
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Memory aids: mascots and interaction avatars
