Curcumin
turmeric
“Curry-Comin'-to-'Merica”
What it isPrincipal curcuminoid of turmeric, inhibiting NF-kB and several inflammatory pathways.
Why this oneThe most studied dietary anti-inflammatory, with modest trial evidence in osteoarthritis.
What limits it⚑ Oral bioavailability is very low, which is why products add piperine — and piperine itself inhibits CYP3A4 and P-gp. Curcumin inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect.
NO BOXED WARNINGS
Principal riskIt inhibits CYP3A4, CYP2C9 and UGT, and can raise warfarin effect
Classes and tags
Clinical profile
Available strengths
- cap 500 mg (95% curcuminoids)
Open Curcumin in the interactive console ↗
Self-check
- Why is piperine added to curcumin products?
Very low oral curcumin bioavailability. - Which transporter does piperine inhibit?
P-gp.