Glutathione
GSH
What it isEndogenous tripeptide (\u03b3-Glu-Cys-Gly): the cell\u2019s main thiol antioxidant and the substrate glutathione S-transferases use to conjugate electrophiles.
Why this oneAcetaminophen overdose exhausts hepatic glutathione, leaving NAPQI free to injure the liver; N-acetylcysteine works by rebuilding it.
What limits itNo FDA-approved product; cysteine supply, not glutathione itself, limits synthesis.
NO BOXED WARNINGS