Urinary pH-sensitive clearance
- Renal elimination changes with urine pH
- Ion trapping drives the effect
- Weak acids clear faster in alkaline urine
- Weak bases clear faster in acidic urine
- Clinical importance depends on renal contribution
Interaction at a glance
- Renal elimination changes with urine pH
Mechanism
- Ion trapping drives the effect
Mechanism / modifiers
- Weak acids clear faster in alkaline urine
- Weak bases clear faster in acidic urine
Mechanism / exceptions
- Renal elimination changes with urine pH
- Clinical importance depends on renal contribution
Self-check
- What does “Urinary pH-sensitive clearance” indicate?
Ion trapping drives the effect.
Drugs in this interaction (12)
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