Smoking interaction (CYP1A2 induction/de-induction)

Interaction at a glance

• Smoke hydrocarbons induce CYP1A2

Mechanism

• Smoke hydrocarbons induce CYP1A2
• Smoking lowers levels of CYP1A2 substrates

Mechanism / modifiers

• Nicotine itself is not the main inducer
• Clozapine/olanzapine are key clinical examples

Magnitude / time course

• Stopping smoking can rapidly raise drug exposure

Self-check

• Which CYP enzyme is induced by cigarette-smoke hydrocarbons?
  CYP1A2.

Drugs in this interaction (24)

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