Polycyclic Aromatic Hydrocarbons
What it isPolycyclic aromatic hydrocarbons from combustion, including tobacco and cannabis smoke.
Why this oneThey are potent CYP1A2 INDUCERS, which is why smokers need higher clozapine, olanzapine and theophylline doses.
What limits it⚑ It is the smoke, not the nicotine — so nicotine replacement does NOT prevent levels rising when a patient stops smoking, and toxicity follows within days.
NO BOXED WARNINGS
Principal risk⚑ Stopping smoking raises clozapine levels sharply within days; nicotine replacement does NOT pr
Classes and tags
Clinical profile
Mechanism of action: Polycyclic Aromatic Hydrocarbons ballicule
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