Melatonin
CIRCADIN
What it isPineal hormone acting at MT1 and MT2 receptors; sleep timing.
Why this oneIts strongest role is circadian phase-shifting, where timing matters more than simply increasing the dose.
What limits itSupplement content may not match the label; verify the product, and adjust timing or stop if next-day sedation occurs.
Off-label
- insomnia
- jet lag
- delayed sleep phase
- REM sleep behavior disorder
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Dietary supplement (sleep) | Adult | 1 tablet QHS | 1 tablet QHS |
Renal Undefined
Hepatic Undefined
Instructions
- Take one tablet 30 minutes before bedtime.
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskUnregulated content; doses in use far exceed physiological
Cost, est. cash$4–$30/month
Classes and tags
Clinical profile
Legacy pregnancy categoryNot assigned — OTC/monograph
Defining liabilityGenerally tolerated at therapeutic doses; clinically important risks are agent-specific and increase with interactions or organ impairment.
Mechanism of action: Melatonin ballicule
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