Protein binding (alpha-1-acid glycoprotein / AAG)
- Basic drug binds mainly to AAG
- AAG rises with stress/inflammation
- Higher AAG can lower unbound fraction
- Total concentration may change without free level change
- Interpret TDM with binding state in mind
Interaction at a glance
- Basic drug binds mainly to AAG
Monitoring
- Basic drug binds mainly to AAG
- AAG rises with stress/inflammation
- Interpret TDM with binding state in mind
Mechanism
- Total concentration may change without free level change
Mechanism / modifiers
- Higher AAG can lower unbound fraction
Self-check
- Can total concentration change without a free-level change when AAG binding changes?
Yes. - When does AAG rise?
Stress/inflammation.
Drugs in this interaction (10)
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