P-gp substrate
- Substrate of P-gp
- P-glycoprotein
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
- Substrate of P-gp
- P-glycoprotein
Mechanism
- Substrate of P-gp
- P-glycoprotein
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- What determines the direction of an inhibitor’s effect on transporter-substrate AUC?
The transporter’s role and kidney, liver or GI location. - What does P-gp stand for?
P-glycoprotein.
Drugs in this interaction (14)
All interaction examples · Open P-gp substrate in the interactive console ↗