P-gp substrate
- Substrate of P-gp
- Transporter changes can alter exposure/distribution
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Interaction at a glance
Mechanism
Magnitude / time course
- Inhibitors may raise or lower AUC by transporter role
- Kidney/liver/GI location determines direction
Exposure modifiers
- Transporter changes can alter exposure/distribution
Self-check
- Which enzyme or transporter is central to the P-gp substrate interaction?
P-gp.
Drugs in this interaction (14)
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