MAO-A substrate
- Metabolized by monoamine oxidase A
- MAO-A inhibition can reduce deamination
- Serotonin/NE-related substrates may accumulate
- Clinical effect depends on alternative pathways
- Not every MAO-A substrate creates a dangerous DDI
Interaction at a glance
- Metabolized by monoamine oxidase A
Mechanism
- Metabolized by monoamine oxidase A
- Not every MAO-A substrate creates a dangerous DDI
Clinical consequence
- Serotonin/NE-related substrates may accumulate
Management
- MAO-A inhibition can reduce deamination
Mechanism / modifiers
- Clinical effect depends on alternative pathways
Self-check
- Which pathway metabolizes a MAO-A substrate?
monoamine oxidase A.
Drugs in this interaction (10)
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