Distribution (large Vd)

Interaction at a glance

• Drug distributes extensively beyond plasma

Mechanism

• Drug distributes extensively beyond plasma
• Plasma concentration reflects only small body fraction

Mechanism / modifiers

• Large Vd usually limits dialysis usefulness
• Lipophilicity/tissue binding often contribute

Management

• Loading dose depends strongly on Vd

Self-check

• What does “Distribution (large Vd)” mean?
  Drug distributes extensively beyond plasma.

Drugs in this interaction (21)

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