CYP3A4 inducer
- Induces CYP3A4 activity/expression
- CYP3A4 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Largest DDI burden; gut + liver both contribute.
Interaction at a glance
- Induces CYP3A4 activity/expression
Mechanism
- Induces CYP3A4 activity/expression
- CYP3A4 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Largest DDI burden; gut + liver both contribute.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- How long does CYP3A4 induction onset/offset usually take?
Over days. - How does CYP3A4 induction affect sensitive-substrate exposure?
It may fall.
Drugs in this interaction (22)
All interaction examples · Open CYP3A4 inducer in the interactive console ↗