CYP3A4 inducer
- Induces CYP3A4 activity/expression
- CYP3A4 substrates usually clear faster
- AUC/effect may fall → treatment failure
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Largest DDI burden; gut + liver both contribute.
Interaction at a glance
- Induces CYP3A4 activity/expression
Mechanism
- Induces CYP3A4 activity/expression
- CYP3A4 substrates usually clear faster
Mechanism / modifiers
- Onset/offset usually takes days
- Strong inducers can affect many co-medications
- Largest DDI burden; gut + liver both contribute.
Clinical consequence
- AUC/effect may fall → treatment failure
Self-check
- Which enzyme or transporter is central to the CYP3A4 inducer interaction?
CYP3A4.
- What usually happens to a sensitive CYP3A4 substrate when a CYP3A4 inducer is added?
Its exposure decreases.
Drugs in this interaction (22)
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