BBB: transporter-sensitive CNS exposure
- CNS exposure depends on active transport
- Efflux or uptake can dominate BBB penetration
- Transporter inhibition may change brain levels
- Plasma AUC may not predict CNS AUC well
- Important for centrally active drugs
Interaction at a glance
- CNS exposure depends on active transport
Mechanism
- Efflux or uptake can dominate BBB penetration
Mechanism / modifiers
- Transporter inhibition may change brain levels
- Important for centrally active drugs
Magnitude / time course
- CNS exposure depends on active transport
- Plasma AUC may not predict CNS AUC well
Self-check
- What does “BBB: transporter-sensitive CNS exposure” indicate?
CNS exposure depends on active transport.
Drugs in this interaction (13)
All interaction examples · Open the interactive console ↗
