Absorption (polyvalent-cation interaction)

Interaction at a glance

• Multivalent cations bind susceptible drugs

Mechanism

• Multivalent cations bind susceptible drugs
• Ca/Mg/Al/Fe are the common culprits

Timing / washout

• Supplements + antacids both count
• Prevent with drug-specific timing separation

Mechanism / modifiers

• Chelation can sharply lower bioavailability

Self-check

• What is the main absorption effect represented by Absorption (polyvalent-cation interaction)?
  Multivalent cations bind susceptible drugs.

Drugs in this interaction (23)

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