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Magnesium oxide

MAG-OX

What it isMagnesium salt acting as an osmotic laxative and repletion agent; constipation and hypomagnesemia.

Why this oneHigh elemental magnesium but poor absorption makes it more reliable as a laxative than as repletion.

What limits itDiarrhea is dose-limiting, and magnesium can accumulate dangerously when kidney function is impaired.

FDA label

FDA dosingPopulationStartTargetMax
AntacidAdults1–2 tablets QD1–2 tablets QD2 tablets/day unless directed by a physician

Renal Undefined

Hepatic Undefined

Label does not state tablet strength (mg).

Pregnancy Undefined

Lactation Undefined

NO BOXED WARNINGS

Principal riskDiarrhea; accumulation in renal impairment

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Magnesium oxide ballicule

Magnesium oxide ballicule: receptor binding, kinetics and half-life diagram

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