Antibacterials (protein-synthesis inhibitors)
- Bind bacterial ribosomes
- Includes macrolides, tetracyclines, AGs
- Also clindamycin + oxazolidinones
- Spectrum/toxicity differ by ribosomal site
- Resistance commonly alters ribosomal binding
- Several have major PK/QT interactions
Class at a glance
- Bind bacterial ribosomes
Practical pearls
- Includes macrolides, tetracyclines, AGs
Other practical pearls
- Resistance commonly alters ribosomal binding
Safety / monitoring
- Also clindamycin + oxazolidinones
- Several have major PK/QT interactions
Safety distinctions
- Spectrum/toxicity differ by ribosomal site
Self-check
- What do Antibacterials (protein-synthesis inhibitors) bind?
Bacterial ribosomes. - Which groups are included in Antibacterials (protein-synthesis inhibitors)?
Macrolides, tetracyclines, AGs.
Drugs in this class (15)
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