Antiarrhythmics (Vaughan-Williams IC)
- Strong Na+ block → marked conduction slowing
- Flecainide/propafenone are prototypes
- Useful for selected AF rhythm control
- Avoid in major structural/ischemic heart disease
- QRS widening is dose/toxicity marker
- Can organize AF into dangerous flutter
Class at a glance
- Strong Na+ block → marked conduction slowing
Practical pearls
- Flecainide/propafenone are prototypes
Clinical role
- Useful for selected AF rhythm control
Safety / monitoring
- Avoid in major structural/ischemic heart disease
- QRS widening is dose/toxicity marker
- Can organize AF into dangerous flutter
Self-check
- When are Antiarrhythmics (Vaughan-Williams IC) especially useful?
Selected AF rhythm control. - When should Antiarrhythmics (Vaughan-Williams IC) generally be avoided?
Major structural/ischemic heart disease.
Drugs in this class (7)
Antiarrhythmics (Vaughan-Williams IC) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026). Class IC highlighted from 1985.
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