Familial hypercholesterolemia (FH)
- Start intensive LDL lowering early
- High-intensity statin is the foundation
- Add ezetimibe then PCSK9-directed therapy as needed
- Homozygous FH often needs specialized agents/apheresis
- Screen first-degree relatives
- Treatment targets lifetime LDL burden
Use at a glance
- Start intensive LDL lowering early
Treatment options
- High-intensity statin is the foundation
Other treatment options
- Add ezetimibe then PCSK9-directed therapy as needed
- Screen first-degree relatives
- Treatment targets lifetime LDL burden
Practical pearls
- Homozygous FH often needs specialized agents/apheresis
Self-check
- What is the treatment foundation for familial hypercholesterolemia?
A high-intensity statin. - What does homozygous FH often need?
Specialized agents/apheresis.
Drugs used for this (7)
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