Clozapine-induced gastrointestinal hypomotility (CIGH)
- Prevention is better than rescue
- Monitor bowel function from clozapine start
- Prefer osmotic + stimulant laxative regimen
- PEG + senna/bisacodyl are common
- Avoid bulk-forming fiber in true hypomotility
- No stool + pain/distention/vomiting = emergency
- Reduce other antimuscarinic burden
Use at a glance
- Prevention is better than rescue
Practical pearls
- Prefer osmotic + stimulant laxative regimen
- PEG + senna/bisacodyl are common
Other practical pearls
- No stool + pain/distention/vomiting = emergency
- Reduce other antimuscarinic burden
Monitoring / follow-up
- Monitor bowel function from clozapine start
- Avoid bulk-forming fiber in true hypomotility
Self-check
- What defines Clozapine-induced gastrointestinal hypomotility (CIGH)?
No stool + pain/distention/vomiting.
- What should generally be avoided in Clozapine-induced gastrointestinal hypomotility (CIGH)?
bulk-forming fiber in true hypomotility.
Drugs used for this (4)
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