Docusate
COLACE
What it isAnionic surfactant marketed to soften stool; constipation prevention and treatment.
Why this oneDespite entrenched use, controlled trials have not shown meaningful benefit over placebo.
What limits it⚑ Minimal toxicity is its main virtue; do not let it displace an effective osmotic or stimulant laxative.
FDA-approved for
- constipation (~1957)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Occasional constipation (stool softener; bowel movement generally in 12–72 h) | ≥12 yr | 1–3 capsules daily (single dose or divided) | 1–3 capsules daily | 3 capsules/day |
| Occasional constipation | 2 to <12 yr | 1 capsule daily | 1 capsule daily | 1 capsule/day |
Renal Undefined
Hepatic Undefined
Do not use a stool softener laxative for more than 1 week
Instructions
- Take only by mouth
- May take as a single daily dose or in divided doses
- Children under 2 years: ask a doctor
Contraindications
- Concurrent mineral oil, unless directed by a doctor
Cautions
- Ask a doctor before use: stomach pain, nausea, vomiting, or a sudden change in bowel habits lasting over 2 weeks
- Stop use and ask a doctor: rectal bleeding, or failure to have a bowel movement after use (possible serious condition)
- Do not use for more than 1 week
Pregnancy If pregnant, ask a health professional before use.
Lactation If breast-feeding, ask a health professional before use.
NO BOXED WARNINGS
Principal riskIt performs no better than placebo
Classes and tags
Clinical profile
Mechanism of action: Docusate ballicule
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