Precursor to metabolite: Divalproex sprinkle to 4-ene-VPA

Divalproex sprinkle is converted to 4-ene-VPA by CYP2C9.

The pair

Divalproex sprinkle — Valproate sprinkle capsule for seizures; useful when intact tablets cannot be swallowed.
4-ene-VPA — Unsaturated valproate metabolite implicated in mitochondrial dysfunction and liver toxicity; not a separate therapeutic drug.

Anything that inhibits or induces CYP2C9 shifts the balance between Divalproex sprinkle and 4-ene-VPA.