4-ene-VPA
from valproate
What it is4-ene-valproic acid, a minor CYP-generated metabolite of valproate implicated in its idiosyncratic hepatotoxicity.
Why it mattersEnzyme-inducing co-medication and very young age push valproate metabolism toward this pathway — the same variables that define the highest-risk group for fatal hepatotoxicity.
What it changesMechanistic explanation, not a lab test: no clinical assay tracks it. Manage risk by avoiding inducer polytherapy in young children.
NO BOXED WARNINGS
Classes and tags
Open 4-ene-VPA in the interactive console ↗
Self-check
- Which co-medication pattern increases the 4-ene-VPA pathway?
Enzyme-inducing co-medication. - Is 4-ene-VPA routinely tracked by a clinical assay?
No.