Precursor to metabolite: Mitragynine to 7-OH-mitragynine
Mitragynine is converted to 7-OH-mitragynine by CYP3A4.
The pair
- Mitragynine — Main kratom alkaloid; mu-opioid partial agonist.
- 7-OH-mitragynine — Kratom's potent mu-opioid metabolite; carries most of the opioid effect and most of the dependence risk.
Anything that inhibits or induces CYP3A4 shifts the balance between Mitragynine and 7-OH-mitragynine.
Mitragynine · 7-OH-mitragynine · Open Mitragynine in the interactive console ↗