Precursor to metabolite: Mitragynine to 7-OHmitragynine
Mitragynine is converted to 7-OHmitragynine by CYP3A4.
The pair
- Mitragynine — The main alkaloid of kratom; a mu-opioid partial agonist.
- 7-OHmitragynine — Kratom's potent mu-opioid metabolite; carries most of the opioid effect and most of the dependence risk.
Anything that inhibits or induces CYP3A4 shifts the balance between Mitragynine and 7-OHmitragynine.
Mitragynine · 7-OHmitragynine · Open Mitragynine in the interactive console ↗