Precursor to metabolite: EXP3179 to EXP3174 (E-3174)
EXP3179 is converted to EXP3174 (E-3174) by CYP2C9.
The pair
- EXP3179 — Losartan's aldehyde intermediate; no AT1 activity, a PPAR-γ partial agonist / COX-2 inhibitor.
- EXP3174 (E-3174) — Losartan's major active metabolite; a more potent, insurmountable AT1 antagonist (CYP2C9/3A4).
Anything that inhibits or induces CYP2C9 shifts the balance between EXP3179 and EXP3174 (E-3174).
EXP3179 · EXP3174 (E-3174) · Open EXP3179 in the interactive console ↗