Precursor to metabolite: Loxapine inhaled to 7-OH loxapine
Loxapine inhaled is converted to 7-OH loxapine by CYP1A2 / CYP3A4.
The pair
- Loxapine inhaled — Inhaled loxapine for acute agitation; single-use inhaler under a bronchospasm REMS.
- 7-OH loxapine — Active metabolite of loxapine; more D2-potent than the parent.
Anything that inhibits or induces CYP1A2, CYP3A4 shifts the balance between Loxapine inhaled and 7-OH loxapine.
Loxapine inhaled · 7-OH loxapine · Open Loxapine inhaled in the interactive console ↗