7-OH loxapine
What it is7-hydroxy metabolite of loxapine, more D2-potent than the parent.
Why it mattersContributes substantially to loxapine’s antipsychotic effect at seemingly modest doses.
What it changesOne of two routes from loxapine; the other, N-demethylation, yields amoxapine and its antidepressant activity.
Used for
- schizophrenia (metabolite of loxapine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Open 7-OH loxapine in the interactive console ↗
Self-check
- How does 7-hydroxyloxapine’s D2 potency compare with loxapine?
Greater than the parent. - What does loxapine N-demethylation produce instead?
Amoxapine, with antidepressant activity.