NMDA glycine-site co-agonist
NMDA glycine co-agonist
- A co-agonist must be present for glutamate to open the channel
- Glycine or D-serine is required for glutamate to activate the receptor
- A co-agonist requirement, not a redundancy
Drugs with this mechanism (4)
- D-Alanine — D-alanine; an NMDA-receptor glycine-site co-agonist amino acid.
- D-Serine — D-serine; an NMDA-receptor glycine-site co-agonist.
- Glycine — Spinal inhibitory neurotransmitter and NMDA co-agonist; also used as urologic irrigation fluid.
- Sarcosine — A GlyT1 inhibitor studied as a schizophrenia adjunct.
Self-check
- Which two co-agonists can satisfy NMDA's co-agonist requirement?
Glycine or D-serine. - Is glutamate alone sufficient to activate the NMDA receptor?
No; a co-agonist must also be present.
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