Norepinephrine releaser
- Reverses the norepinephrine transporter → norepinephrine exits independent of firing
- ↑ heart rate and blood pressure
- Effect wanes as vesicular stores deplete
- The sympathomimetic amine mechanism
Drugs with this mechanism (18)
- Mixed amphetamine salts XR — Extended-release stimulant for ADHD; long coverage with Schedule II misuse risk.
- Amphetamine XR-ODT — Extended-release orally disintegrating amphetamine for ADHD; no pill swallowing needed.
- Mixed amphetamine salts — Monoamine-releasing stimulant for ADHD and narcolepsy; effective but readily misused.
- Cathinone — Khat stimulant; the parent of the synthetic cathinone ("bath salt") class.
- Dextroamphetamine — Pure d-amphetamine stimulant for ADHD and narcolepsy; tablet, solution, Spansule and patch.
- Dextroamphetamine spansule — Extended-release dextroamphetamine; the active amphetamine enantiomer for ADHD.
- Dextroamphetamine oral solution — Liquid dextroamphetamine for ADHD; flexible measurement but full stimulant misuse risk.
- Amphetamine XR suspension — Extended-release liquid amphetamine for ADHD; useful when pills are difficult.
- Amphetamine racemic (1:1) — Racemic amphetamine for ADHD; more peripheral sympathomimetic effect than dextro-rich products.
- Methylenedioxymethamphetamine — Serotonin releaser (empathogen) under study for PTSD.
- Methamphetamine — Potent, CNS-penetrant amphetamine; high addiction liability, rare medical use.
- Mixed amphetamine salts (triple-bead) — Triple-bead extended-release mixed amphetamine salts for all-day ADHD coverage.
- Phendimetrazine — Sympathomimetic weight-loss agent; prodrug of phenmetrazine.
- Phentermine — Amphetamine-like appetite suppressant for short-term weight loss.
- Pseudoephedrine — Oral norepinephrine-releasing decongestant; effective but purchase-restricted.
- Tyramine — Dietary trace amine that triggers hypertensive crisis with MAOIs.
- Dextroamphetamine patch — Transdermal dextroamphetamine for ADHD; wear time can shape late-day exposure.
- Dextroamphetamine IR tablets — Immediate-release dextroamphetamine for ADHD or narcolepsy; effective stimulant with appetite, sleep, cardiovascular, and misuse concerns.
Self-check
- Does norepinephrine release through reversed NET require neuronal firing?
No; norepinephrine exits independently of firing. - Why does the NET-releaser effect wane?
Vesicular stores become depleted.
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