Dextroamphetamine IR tablets
ZENZEDI
What it isDextroamphetamine IR tablets (ZENZEDI, 2013) — Seven strengths, 2.5-30 mg.
Why this oneDuration of action 3-5 h (Carlat Table 1); same molecule and elimination kinetics as the parent — the formulation is the difference.
What limits itApproved ages (ADHD label): 3-16. Class warnings of the parent molecule apply.
FDA-approved for
- ADHD (2013)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Narcolepsy | Adults and pediatric ≥6 y | 5 mg/day (6–12 y) or 10 mg/day (≥12 y) | 5–60 mg/day in divided doses | 60 mg/day |
| Attention Deficit Disorder with Hyperactivity | Pediatric 3–16 y | 2.5 mg/day (3–5 y) or 5 mg QD–BID (≥6 y) | 40 mg/day |
Titration Increase in weekly increments (2.5 mg for 3–5 y; 5 mg for ≥6 y / 6–12 y narcolepsy; 10 mg for ≥12 y narcolepsy)
Renal Undefined
Hepatic Undefined
Instructions
- Use lowest effective dosage; give first dose on awakening
- Avoid late evening doses (insomnia)
- Give additional doses (1 or 2) at 4–6 h intervals
Contraindications
- During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result)
Cautions
- Serious cardiac disease/sudden death
- Increased blood pressure and heart rate
- Psychiatric adverse reactions (psychosis/mania)
- Long-term growth suppression in pediatrics
- Seizures (lowered threshold)
- Peripheral vasculopathy incl. Raynaud's phenomenon
- Serotonin syndrome
- Motor/verbal tics, worsening of Tourette's
Adverse reactions
- Palpitations
- Tachycardia
- Elevated blood pressure
- Overstimulation/restlessness
- Insomnia
- Dizziness
- Dyskinesia
- Tremor
- Headache
- Dry mouth
- Diarrhea/constipation
- Anorexia/weight loss
Pregnancy Pregnancy Category C; use only if potential benefit justifies risk to fetus
Lactation Amphetamines are excreted in human milk; mothers should refrain from nursing
⚠ BOXED WARNING
- Abuse, misuse and addiction
Classes and tags
Clinical profile
Mechanism of action: Dextroamphetamine IR tablets ballicule
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