Mu-opioid antagonist
Mu-opioid receptor antagonist
Drugs with this mechanism (11)
- Alvimopan — Peripheral mu antagonist speeding gut recovery after bowel surgery.
- Methylnaltrexone — Peripheral mu antagonist for opioid-induced constipation.
- Nalbuphine — Mixed opioid agonist-antagonist analgesic with a ceiling on respiratory depression.
- Naldemedine — Peripheral mu-opioid antagonist for opioid-induced constipation; no food restriction.
- Nalmefene — Long-acting intranasal opioid antagonist for overdose reversal.
- Naloxegol — Oral peripheral mu antagonist for opioid-induced constipation.
- Naloxone — Short-acting opioid antagonist; the overdose-reversal agent.
- Naloxone nasal spray — OTC intranasal mu-opioid antagonist for community overdose reversal; repeat doses may be needed.
- Naltrexone — Opioid antagonist for alcohol and opioid use disorder; monthly injectable option.
- Samidorphan — Mu antagonist added to olanzapine to blunt weight gain.
- Naltrexone ER injection — Extended-release injectable naltrexone for alcohol and opioid use disorders.
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