Urinary pH (acidification ↑ clearance)
- Acidic urine increases excretion of weak bases
- More ionized drug is trapped in urine
- Effect requires meaningful renal elimination
- Deliberate urine acidification is rarely used
- pKa determines magnitude
Interaction at a glance
- Acidic urine increases excretion of weak bases
Mechanism
- Acidic urine increases excretion of weak bases
- More ionized drug is trapped in urine
Mechanism / modifiers
- Deliberate urine acidification is rarely used
- pKa determines magnitude
Mechanism / exceptions
- Effect requires meaningful renal elimination
Self-check
- How does acidic urine increase weak-base excretion?
More ionized drug is trapped in urine. - Is deliberate urinary acidification commonly used?
No; rarely.
Drugs in this interaction (7)
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