Tyramine interaction
- Gut/liver MAO-A normally metabolizes tyramine
- MAO-A inhibition lets tyramine reach circulation
- NE release can cause hypertensive crisis
- Risk is highest with irreversible/nonselective MAOIs
- Dietary restriction depends on MAO-A inhibition
Interaction at a glance
- Gut/liver MAO-A normally metabolizes tyramine
Mechanism
- Gut/liver MAO-A normally metabolizes tyramine
- MAO-A inhibition lets tyramine reach circulation
- Dietary restriction depends on MAO-A inhibition
Clinical consequence
- Risk is highest with irreversible/nonselective MAOIs
Mechanism / modifiers
- NE release can cause hypertensive crisis
Self-check
- Where is tyramine normally metabolized by MAO-A?
Gut/liver. - What can tyramine-mediated NE release cause?
Hypertensive crisis.
Drugs in this interaction (9)
All interaction examples · Open Tyramine interaction in the interactive console ↗