Tyramine interaction
- Gut/liver MAO-A normally metabolizes tyramine
- MAO-A inhibition lets tyramine reach circulation
- NE release can cause hypertensive crisis
- Risk is highest with irreversible/nonselective MAOIs
- Dietary restriction depends on MAO-A inhibition
Interaction at a glance
- Gut/liver MAO-A normally metabolizes tyramine
Mechanism
- Gut/liver MAO-A normally metabolizes tyramine
- MAO-A inhibition lets tyramine reach circulation
- Dietary restriction depends on MAO-A inhibition
Clinical consequence
- Risk is highest with irreversible/nonselective MAOIs
Mechanism / modifiers
- NE release can cause hypertensive crisis
Self-check
- What pharmacokinetic or pharmacodynamic feature does “Tyramine interaction” represent?
Gut/liver MAO-A normally metabolizes tyramine.
Drugs in this interaction (9)
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