St John's wort interaction

Interaction at a glance

• Potent inducer of CYP3A and P-gp

Mechanism

• Potent inducer of CYP3A and P-gp
• Induction persists after stopping
• Hyperforin content varies across products

Clinical consequence

• Contraceptive/antiviral/transplant failures are concerns

Magnitude / time course

• Can lower exposure of many oral drugs

Self-check

• What major clinical effect is associated with St John's wort interaction?
  Contraceptive/antiviral/transplant failures are concerns.

Drugs in this interaction (22)

All interaction examples · Open the interactive console ↗