Seizure-threshold lowering

Interaction at a glance

• Increases probability of a seizure

Mechanism

• Multiple proconvulsant drugs can stack

Clinical consequence

• Increases probability of a seizure
• Epilepsy, withdrawal + metabolic stress add risk

Who is at greatest risk

• Risk usually rises with dose/exposure
• Avoid abrupt changes that further destabilize threshold

Self-check

• What happens to seizure risk as dose/exposure rises?
  It generally increases.
• Can multiple proconvulsant drugs add to seizure risk?
  Yes.

Drugs in this interaction (27)

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