Rhabdomyolysis/myopathy

Interaction at a glance

• Can injure skeletal muscle

Mechanism

• Can injure skeletal muscle

Mechanism / modifiers

• Myalgia/weakness may precede CK elevation
• Statin interactions are a classic example

Clinical consequence

• Severe injury → rhabdomyolysis + AKI
• Exposure-raising DDIs can greatly increase risk

Self-check

• What is the main clinical risk of Rhabdomyolysis/myopathy?
  Severe injury → rhabdomyolysis + AKI.
• What major clinical effect is associated with Rhabdomyolysis/myopathy?
  Exposure-raising DDIs can greatly increase risk.

Drugs in this interaction (17)

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