Rhabdomyolysis/myopathy
- Can injure skeletal muscle
- Myalgia/weakness may precede CK elevation
- Severe injury → rhabdomyolysis + AKI
- Exposure-raising DDIs can greatly increase risk
- Statin interactions are a classic example
Interaction at a glance
- Can injure skeletal muscle
Mechanism
- Can injure skeletal muscle
Mechanism / modifiers
- Myalgia/weakness may precede CK elevation
- Statin interactions are a classic example
Clinical consequence
- Severe injury → rhabdomyolysis + AKI
- Exposure-raising DDIs can greatly increase risk
Self-check
- Key risk with Rhabdomyolysis/myopathy?
Severe injury → rhabdomyolysis + AKI. - Key clinical effect of Rhabdomyolysis/myopathy?
Exposure-raising DDIs can greatly increase risk.
Drugs in this interaction (17)
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