Orthostasis

Interaction at a glance

• BP falls on standing

Mechanism

• BP falls on standing
• Alpha blockade/vasodilation/autonomic effects common

Mechanism / modifiers

• Dizziness, falls + syncope can result
• Slow titration can improve tolerance

Clinical consequence

• Dehydration and multiple BP drugs magnify risk

Self-check

• What major clinical effect is associated with Orthostasis?
  BP falls on standing.

Drugs in this interaction (24)

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