Orthostasis

Interaction at a glance

• BP falls on standing

Mechanism

• BP falls on standing
• Alpha blockade/vasodilation/autonomic effects common

Mechanism / modifiers

• Dizziness, falls + syncope can result
• Slow titration can improve tolerance

Clinical consequence

• Dehydration and multiple BP drugs magnify risk

Self-check

• Key clinical effect of Orthostasis?
  BP falls on standing.
• What titration strategy can improve orthostatic tolerance?
  Slow titration.

Drugs in this interaction (25)

All interaction examples · Open Orthostasis in the interactive console ↗