MAO-A inhibitor
- Inhibits monoamine oxidase A
- Reduces metabolism of serotonin/NE/tyramine
- Strong inhibition creates major DDI risk
- Potent SRIs/releasers can cause severe serotonin toxicity
- Tyramine risk depends on gut/liver MAO-A blockade
Interaction at a glance
- Inhibits monoamine oxidase A
Mechanism
- Inhibits monoamine oxidase A
Clinical consequence
- Strong inhibition creates major DDI risk
- Potent SRIs/releasers can cause severe serotonin toxicity
- Tyramine risk depends on gut/liver MAO-A blockade
Who is at greatest risk
- Reduces metabolism of serotonin/NE/tyramine
Self-check
- What life-threatening toxicity can potent SRIs/releasers cause with MAO-A inhibition?
Severe serotonin toxicity.
- What dietary risk depends on gut/liver MAO-A blockade?
Tyramine toxicity.
Drugs in this interaction (13)
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