Ionization (weak base)
- Basic drug is more unionized at high pH
- Acidic compartments can ion-trap the drug
- Urine acidification may increase renal trapping
- Many lipophilic CNS drugs are weak bases
- pKa determines how much is charged
Interaction at a glance
- Basic drug is more unionized at high pH
Mechanism
- Basic drug is more unionized at high pH
- Acidic compartments can ion-trap the drug
Mechanism / modifiers
- Many lipophilic CNS drugs are weak bases
- pKa determines how much is charged
Mechanism / exceptions
- Urine acidification may increase renal trapping
Self-check
- What does “Ionization (weak base)” mean?
Basic drug is more unionized at high pH.
Drugs in this interaction (7)
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